Preventing Atopic Dermatitis and ALLergies in Children - the PreventADALL study
Carlsen, K. C. L, *Rehbinder, E. M, *Skjerven, H. O, Carlsen, M. H, Fatnes, T. A Fugelli, P, Granum, B, Haugen, G, Hedlin, G, Jonassen, C. M, Landrø, L, Lunde, J, Marsland, B. J, Nordlund, B, Rudi, K, Sjøborg, K, Söderhäll, C, Staff, A. C, Vettukattil, R, Carlsen, K. H. *Equal contribution. Allergy. 2018; DOI: 10.1111/all.13468
This first paper of the PreventADALL study, describes this large randomized controlled, prospective general mother-child-cohort study. It was established at 18-week pregnancy and is planned for follow-up investigations into adult age of the child. The paper describes the background, aims, methods of the study, as well as describing the included cohort, consisting of 2701 pregnant women and their babies, comprising 2397 mother-child pairs. The recruitment of women was completed within 22 months from December 2014, and the last baby was born in April 2017. The study is unique within primary prevention of allergy, by the 2x2 intervention strategy targeting both skin and gastro-intestinal tract.
Is amniotic fluid of women with uncomplicated term pregnancies free of bacteria?
Rehbinder, E. M, *Lodrup Carlsen, K. C, *Staff, A. C, Angell, I. L., Landrø, L, Hilde, K., Gaustad, P, Rudi, K. *Equal contribution. Am J Obstet Gynecol. 2018; DOI: 10.1016/j.ajog.2018.05.028
Recently, the view that amniotic fluid does not have live bacterial communities present in uncomplicated term pregnancies has been challenged by several studies. In this paper we present our findings, which support a sterile amniotic fluid until the start of the labour.
Dry skin and skin barrier in early infancy
*Rehbinder, E. M, *Winger, A. J, Landrø, L, Asarnoj, A, Berents, T. L, Carlsen, K. H Hedlin, G, Jonassen, C. M, Nordlund, B, Sandvik, L, Skjerven, H. O, Söderhäll, C, Vettukattil, R, Carlsen, K. C. L. *Equal contribution. . Br J Dermatol. 2019; DOI: 10.1111/bjd.17626
In this paper we present findings in three-month old infants, where 59 % had dry skin, most commonly observed on the cheeks and extensor surfaces of the extremities. Dry skin without the presence of clinical eczema was observed in 47 % of the infants and was significantly associated with reduced skin barrier function (measured by transepidermal waterloss) than in infants without the presence of dry skin or clinical eczema. The reduced skin barrier function appeared to be more pronounced in infants with dry skin affecting both cheeks and extensor areas.
Predicting skin barrier dysfunction and atopic dermatitis in early infancy
Rehbinder, E. M, Endre, K.A, Carlsen, K. C. L, Asarnoj, A, Bains, K.E.S, Berents, T. L, Carlsen, K. H, Gudmundsdóttir, H.K, Haugen, G, Hedlin, G, Kreyberg, I, Nordhagen, L, S, Nordlund, B, Sandvik, L, Saunders, C, M, Skjerven, H. O, Söderhäll, Staff, A.C, Vettukattil, R, Værnesbranden, M.R, Landrø, L. . Manuscript accepted 17.09.19 in JACI: In Practice
Skin barrier dysfunction has been found to precede atopic dermatitis. Dry skin is associated with higher transepidermal waterloss. The article reveals distinctive factors predictive for dry skin, high TEWL and AD at 3 months of age. Dry skin at 3 months was predictive for AD three months later. Recognizing predictive factors for AD early in life may help targeting infants for primary prevention of AD.
Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
Read the article here
The statistical analysis plan for the study is found here