Radiotherapy (RT) reduces pain in about 60% of patients with painful bone
metastases, but there are no available predictors to select patients to receive
or not receive RT, leaving many patients without clinical benefit.
The PRAIS study is the first
prospective study designed to investigate predictors of RT response in patients with painful bone metastases. In this international
multicenter study we have assessed predictors for RT effectiveness in 513
We found that performance status is one of the most important variables
to predict RT response. Response rates more than doubled in patients with
Karnofsky performance status >80 compared to performances status <50.
Patients with a cancer diagnosis of breast or prostate cancer and patients with
soft tissue expansion outside bone did also have significantly better response
rates, while the use of corticosteroids was a negative predictor for RT
response in patients with painful bone metastases. These results may be helpful in selecting patients
for palliative RT.
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