Exercise training is included in the guidelines for prevention, treatment and rehabilitation of a broad spectrum of the most prevalent cardiovascular conditions. Not only can exercise training be a treatment in itself, but the cellular mechanisms underlying the benefit has also been used as a means to reveal new molecular targets in the search for novel treatments for heart failure.Exercise
training following development of heart failure shifted the cardiac phenotype back towards
normal in an exercise intensity-dependent manner based on key parameters
ranging from whole body exercise capacity, systolic and diastolic cardiac
function as well as susceptibility for cardiac ventricular fibrillation, to underpinning mechanisms
at the cellular level with restoration of cardiomyocyte function, calcium handling and electrophysiological
properties. This study showed that a magnitude of improvements in calcium handling and electrophysiological properties are exercise intensity dependent, indicating that high intensity exercise is superior to moderate intensity on reducing disposition for irregular heartbeats.
Read more in;
Exercise training reveals micro-RNAs
associated with improved cardiac function and electrophysiology in rats with
heart failure after myocardial infarction - PubMed (nih.gov)
J Mol Cell Cardiol. 2020 Nov;148:106-119.
Tomas O Stølen, Morten A Høydal, Muhammad Shakil
Ahmed, Kari Jørgensen, Karin Garten, Maria P Hortigon-Vinagre, Victor
Zamora, Nathan R Scrimgeour, Anne Marie Ormbostad Berre, Bjarne
M Nes, Eirik Skogvoll, Anne Berit Johnsen, Jose B N Moreira, Julie
R McMullen, Håvard Attramadal, Godfrey L Smith, Øyvind Ellingsen, Ulrik
Wisløff
PMID: 32918915
DOI:
10.1016/j.yjmcc.2020.08.015
Short excerpts from the article shared under Elsevier license number 5515400146093