Brugada syndrome: Drugs in pregnancy (BrS-DIP)
BrS-DIP is a multicenter retrospective study investigating the anesthetic management of women with Brugada syndrom or genotype SCN5A during pregnancy and delivery. Brugada syndrome is a rare genetic cardiac condition which implies impaired voltage-gated sodium channels which affect the electrophysiology of heart muscle cells. This results in an increased risk of ventricular tachyarrhythmias and sudden cardiac death. The arrhythmogenic risk associated with BrS is increased by various metabolic and pharmacological factors, and the setting of pregnancy and anesthesia is therefore challenging.
The study objective is to collect clinical data on women with Brugada syndrom (BrS), and all SCN5A genotype positive subjects and history of at least one pregnancy. The main aim of the study is to improve safety in anesthetic management during pregnancy and delivery in women with BrS.
Researchers involved
- Anna Sørlie, MD/PhD-fellow, OUS
- Project leader and co-supervisor: Kristina Haugaa, MD/Professor, OUS/UiO
- Main-supervisor: Mette-Elise Estensen, MD/PhD, OUS
- Co-supervisor: Nina Eide Hasselberg, MD/PhD, OUS