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Forskning ved KLB
Forskningsaktiviteten ved KLB er tilknyttet European Palliative Care Research Centre
(PRC). PRC er lokalisert ved OUS og Universitetet i Oslo (UiO). Forskningsgruppen er integrert i PRC og er tverrfaglig sammensatt. Dette sikrer spisskompetanse på sentrale områder innen palliativ medisin.
Målet er å drive forskning av høy internasjonal kvalitet til beste for pasienter, helsevesen og samfunn.
Det er etablert forskningssamarbeid med andre miljøer på OUS, med UiO og OsloMet, med NTNU og de andre regionale kompetansetjenester. Det er også etablert forskningssamarbeid i regionen og med internasjonale samarbeidspartnere.
Hovedområder for forskningsvirksomheten: • Depresjon og psykisk distress • Ernæring/kachexi • Helsetjenesteforskning • Hjernemetastaser • Integrasjon onkologi og palliasjon • Spørreskjemametodikk
Har du spørsmål til forskningen ved KLB ta kontakt med enhetsleder
Torunn Wester
The PALLiON study – (Palliative Care Integrated in Oncology), a national cluster randomized trial on early integration of oncological and palliative care
Brain Metastases in Norway - A Prospective Cohort Study, a 2 year follow-up of patients with newly diagnosed brain metastases; clinical and treatment related patient self-reported data
PRAIS - The Palliative Radiotherapy and Inflammation Study, a large international observational study aiming to investigate predictors of response of radiotherapy in patients with painful bone metastases
MENAC - The Multimodal Exercise/Nutrition/Anti-inflammatory treatment for Cachexia trial, a large-scale international open randomized phase III multimodal intervention trial investigating the effect of a tripod intervention as early prevention of the development of cachexia
PROMsPOL Implementation of care pathways with systematic patient-reported outcomes measures (PROMs) in cancer outpatient care; a randomized controlled trial
PARASTOP - Paracetamol with strong opioids for moderate to severe cancer pain
MyPath - To develop digital patient-centred care pathways with incorporated patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) for shared decision-making between patients and health care providers. The main ambition for the project is to deliver a sustainable solution for cancer patients for improved supportive, palliative, survivorship and end-of-life care. The innovative MyPath, based upon scientific evidence, will improve the quality of life of patients and family, promote patient empowerment and change the way healthcare providers work.
MATRIX – Multimodal Approach targeting Treatment-Refractory cancers using next-generation technologies and trials.
Nytt forskningssenter som skal utvikle og etablere ny diagnostikk, bl.a. pasientrapportert diagnostikk for at pasienter kan behandles mer presist, med større effekt og økt pasientmedvirkning. PRC leder to arbeidspakker som omhandler pasientsentrert behandling, helsetjenesteforskning og implementering.
MultiAnam – Multimodal treatment including anamorelin in patients suffering from cancer cachexia. A randomized controlled trial.
The objective is to evaluate efficacy of anamorelin as part of a multimodal cachexia intervention in terms of improving body weight (primary) and physical performance (secondary) in patients with inoperable pancreatic cancer.
Bye A, Bjerkeset E, Stensheim H, Loge JH, Hjermstad MJ, Klepstad P, Habberstad R, Kaasa S, Aass N. Benefits of Study Participation for Patients with Advanced Cancer Receiving Radiotherapy: A Prospective Observational Study. Palliative Medicine Reports. 2022;3(1):264-71.
Lundeby T, Finset A, Kaasa S, Wester TE, Hjermstad MJ, Dajani O, et al. A complex communication skills training program for physicians providing advanced cancer care–content development and barriers and solutions for implementation. Journal of communication in healthcare. 2022. Tilgjengelig fra: https://www.tandfonline.com/doi/full/10.1080/17538068.2022.2039468
Karlsson AT, Hjermstad MJ, Omdahl T, Aass N, Skovlund E, Hellebust TP, et al. Overall survival after initial radiotherapy for brain metastases; a population based study of 2140 patients with non-small cell lung cancer. Acta Oncol. 2021;60(8):1054-60. Tilgjengelig fra: https://www.tandfonline.com/doi/full/10.1080/0284186X.2021.1924399
Winther RR, Vik-Mo EO, Yri OE, Aass N, Kaasa S, Skovlund E, et al. Surgery for brain metastases - real-world prognostic factors' association with survival. Acta Oncol. 2021;60(9):1161-8. Tilgjengelig fra: https://www.tandfonline.com/doi/full/10.1080/0284186X.2021.1930150
Habberstad R, Frøseth TCS, Aass N, Bjerkeset E, Abramova T, Garcia-Alonso E, et al. Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases. J Pain Symptom Manage. 2021;62(4):681-90. 10. DOI: 10.1016/j.jpainsymman.2021.03.022
Gullhaug A, Hjermstad MJ, Yri O, Svestad JG, Aass N, Johansen S. Use of radiotherapy in breast cancer patients with brain metastases: a retrospective 11-year single center study. J Med Imaging Radiat Sci. 2021;52(2):214-22. Tilgjengelig fra: https://www.sciencedirect.com/science/article/pii/S1939865421000023?via%3Dihub
Hjermstad MJ, Aass N, Andersen S, Brunelli C, Dajani O, Garresori H, et al. PALLiON - PALLiative care Integrated in ONcology: study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care. Trials. 2020;21(1):303. Tilgjengelig fra: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118863/pdf/13063_2020_Article_4224(PDF)
Lundeby T, Wester TE, Loge JH, Kaasa S, Aass NK, Grotmol KS, et al. Challenges and Learning Needs for Providers of Advanced Cancer Care: Focus Group Interviews with Physicians and Nurses. Palliat Med Rep. 2020;1(1):208-15. Tilgjengelig fra: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241352/pdf/pmr.2020.0059(PDF)
Balstad TR, Brunelli C, Pettersen CH, Schønberg SA, Skorpen F, Fallon M, et al. Power Comparisons and Clinical Meaning of Outcome Measures in Assessing Treatment Effect in Cancer Cachexia: Secondary Analysis From a Randomized Pilot Multimodal Intervention Trial. Front Nutr. 2020;7:602775. Tilgjengelig fra: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874039/pdf/fnut-07-602775(PDF)
Habberstad R, Frøseth TCS, Aass N, Abramova T, Baas T, Mørkeset ST, et al. The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain. BMC Palliat Care. 2018;17(1):110. Tilgjengelig fra: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162927/pdf/12904_2018_Article_362(PDF)
European Palliative Care Research Centre (PRC)
PRC is a European research centre consisting of 18 collaborating centers. We plan and conduct international multicentre studies within palliative care, focusing on pain, cachexia and health care services.
