Resultater fra NOSVAR og publikasjonsliste
Totalt har NOSVAR bidratt til mer enn 100 vitenskapelige internasjonale manuskripter, alle oppført i forskningsdatabasen Pubmed. Data fra NOSVAR er også brukt i 9 medisinske PhD (doktorgrad).
Figuren viser antall publikasjoner per år i perioden 2010-2020

Pågående samarbeid nasjonalt og internasjonalt
Her kan du lese om forskning som helt- eller delvis er basert på NOSVAR-data. Forskningsaktiviteten gjenspeiler hva pasientenes data brukes til for tiden
SYSTEMISK SKLEROSE
IG COATING AV TARMBAKTERIER VED TIDLIG SSC
Prosjektansvarlig: MD PhD (post.doc) Anna-Maria Hoffmann-Vold
Samarbeidspartner: post. doc Brian Chung (Norsk senter for PSC), Kristofer Andreasson og Roger Hesselstrand, Revmatologisk avdeling, Lund Universitetssykehus
REK sør-øst: 2014/2330 Tarmens bakterieflora ved systemisk sklerose
Abstract presentert på EULAR 2020. Artikkel skrives
RESSCUE STUDIEN: TRANSPLANTASJON AV TARMBAKTERIER VED SYSTEMISK SKLEROSE
Prosjektleder: prof. dr. med Øyvind Molberg, MD PhD (post. doc) Anna-Maria Hoffmann-Vold.
REK helse-sør: 2016/1529 Standardisert fekal mikrobiota transplantasjon ved systemisk sklerose
Nasjonal samarbeids-studie: Oslo universitets sykehus, St. Olavs hospital, Trondheim, Universitetssykehuset Nord-Norge, Tromsø, Haukeland universitetssykehus, Bergen, Karolinska institutet. En internasjonal ekspertgruppe på systemisk sklerose er etablert i forbindelse med studien: Oliver Distler (Zurich, Switzerland), Dinesh Khanna (Michigan, USA) og Elizabeth Volkmann (UCLA, USA). 30 pasienter fra NOSVAR er screenet, 18 er inkludert.
INTERSTITIELL LUNGE SYKDOM VED SYSTEMISK SKLEROSE: CYTOKINER OG BILDE DIAGNOSTIKK
Prosjektansvarlig: MD Ph.D (post. doc) Anna-Maria Hoffmann-Vold
Samarbeidspartner: MD John Belperio (lungeavdeling), Grace Kim og Jonathan Goldin (radiologisk avdeling) UCLA (University of California), Los Angeles, USA
REK sør-øst: 2017/1816 Interstitiell lungesykdom ved SSc
Hovedmålet med studien er å identifisere cytokiner som kan være assosiert med interstitiell lungesykdom (ILD) eller PH ved SSc og som kan brukes som prediktorer for sykdoms progresjon eller dårlig utfall. Serum på 379 SSc pasienter og 100 kontroller ble sendt fra NOSVAR til UCLA (University of California, Los Angeles) til analyse av 4 paneler med cytokiner og angio-genetiske faktorer med Luminex teknologi. Publikasjon i 2020. Inkludert fra Biobanken ca. 2000 HRCT bilder fra ca. 500 SSc pasienter til kvantifisering av lungeforandriger. Studien pågår.
LONGITUDINAL ANALYSIS OF ANTI-TOPOISOMERASE I AND ANTICENTROMERE ANTIBODY LEVELS, AND OTHER CHARACTERISTICS IN PATIENTS WITH SYSTEMIC SCLEROSIS
Prosjekt-tittel: Longitudinal analysis of anti-topoisomerase I and anticentromere antibody levels, and other characteristics in patients with systemic sclerosis.
Prosjektansvarlig: J.K. de Vries-Bouwstra, revmatologisk avdeling, Leiden University Medical Center, Netherlands
Prosjektmedarbeider: Anna-Maria Hoffmann-Vold, MD Ph.D OUS
REK sør-øst: 2016/685 Genetiske markører ved systemiske, autoimmune sykdommer.
NOSVAR biobanken har bidratt med 32 serumprøver til studien. Planlagt felles studie for å se på longitudinelle GI symptomer målt med UCLA-Git skår. Ca. 500 SSc pasienter fra NOSVAR og ca. 400 fra Leiden. Publikasjon på ATA (anti-topoisomerase I) ble publisert i 2019 og ACA (anticentromer) ble i 2020 sendt inn og er nå under review.
IMPACT OF STANDARD OF CARE TREATMENT ON GASTROINTESTINAL INVOLVEMENT IN PATIENTS WITH SYSTEMIC SCLEROSIS
Prosjektansvarlig: MD Ph.D (postdoc) Anna-Maria Hoffmann-Vold.
Prosjektmedarbeider: J.K. de Vries-Bouwstra, revmatologisk avdeling, Leiden University Medical Center, Netherlands
REK sør-øst:
Artikkel er under review.
RADIOMICS IN THE DIAGNOSIS OF ILD IN SSC
Prosjektansvarlig: MD PhD Britta Maurer, University Hospital of Zurich, Sveits
Prosjektmedarbeider: MD PhD (posdoc) Anna-Maria Hoffmann-Vold, Håvard Fretheim
REK sør-øst: 2017/1816 Interstitiell lungesykdom ved SSc
Kliniske data og HRCT fra SSc pasienter i NOSVAR er inkludert i studien. Oral presentasjon av data på EULAR og Word congress of Systemic sclerosis . Artikkel under skriving.
ANALYSE AV TARMBIOPSIER AV RESSCUE PASIENTER FRA PILOTSTUDIEN
Prosjektansvarlig: MD PhD (posdoc) Anna-Maria Hoffmann-Vold
Prosjektmedarbeider: Gabriela Kani, Oliver Distler, University Hospital of Zurich, Sveits, Henriette Didriksen, OUS
REK sør øst: 2016/1529 Standardisert fekal mikrobiota transplantasjon ved systemisk sklerose
RESCUE pilot studie er tidligere omtalt i årsrapporten 2018. Artikkel publisert i 2020.
INSIDENS AV RENAL KRISE VED SSC
Prosjektansvarlig: Scleroderma Clinical Trials Consortium (SCTC), USA, multicenter studie
Prosjektmedarbeider: MD PhD (posdoc) Anna-Maria Hoffmann-Vold
Rek sør øst: REK (2016/119). NOSVAR
SRC (scleroderma renal crisis) er en arbeidsgruppe under SCTC som ble dannet i 2015 og består av internasjonale eksperter innen revmatologi, nevrologi og patologi. Gruppen jobber med utvikling og validering av klassifikasjonskriterier av renal krise (SRC). Hensikten med samarbeidet er å måle insidensen av renal krise i en større populasjon.
GPA–WEGENERS GENETIKK STUDIE PÅ ANCA ASSOSIERT VASKULITT (UNIVERSITETET I UPPSALA)
Prosjekttittel ”Identifiering och funktionella studier av genetiska riskfaktorer för ANCA-associerade vaskuliter”.
REK sør-øst: 2009/128 Genetiske markører ved systemiske, autoimmune sykdommer.
Prosjektleder: Johanna Dahlqvist, Institutionen för medicinsk biokemi och mikrobiologi, Uppsala universitet. Medarbeider: Øyvind Palm, OUS. Dette er et genetikk-samarbeidsprosjekt om ANCA assosierte vaskulitter mellom universitetssykehusene i Uppsala, Umeå, Linköping, Lund/Malmö, Karolinska sjukhuset i Solna/Huddinge og Revmatologisk seksjon Oslo Universitetssykehus, Rikshospitalet. Analyser pågår.
Årsrapport NOSVAR 2020 Side 15
MYOSITTER/SJØGREN/SLE
GENETISKE MARKØRER VED SYSTEMISKE, AUTOIMMUNE SYKDOMMER (DISSECT STUDIEN), UNIVERSITETET I UPPSALA, SVERIGE
Prosjektansvarlig: professor dr.med Øyvind Molberg
Prosjektmedarbeidere: Seksjon for revmatologi, OUS: Øyvind Palm, Helena Andersson, Karoline Lerang, Universitetet i Uppsala: Lars Rönnblom, Johanna Sandling
Rek sør-øst: 2016/685 Genetiske markører ved systemiske, autoimmune sykdommer.
DISSECT-studien er et Astra Zeneca (AZ)-Scilifelab-nordisk myositt samarbeidsprosjekt under ledelse av Professor Lars Rönnblom ved universitetet i Uppsala. Hensikten er å kartlegge koblingen mellom genetiske variasjon, immunologiske avvik og kliniske symptom ved tre ulike systemiske autoimmune sykdommer; SLE, Sjøgrens syndrom og myositt. Prosjektkoordinator er Johanna Sandling. DNA fra 155 myositt-pasienter fra NOSVAR biobanken ble inkludert i 2015. Serum fra de samme pasientene ble sendt i mai 2016. I 2017 er det i tillegg utlevert 143 EDTA av Sjøgren pasienter. Uttak er også gjort på 400 EDTA SLE som ble sendt i januar 2018. I mars 2019 ble samarbeidsprosjektet med Astra Zeneca (AZ)-Scilifelab avsluttet. Totalt 22 vitenskapelige publikasjoner (artikler og abstracts) er publisert i løpet av samarbeidsperioden. Data vil fortsatt bli analysert av Dissect akademia og flere studier er pågående. En artikkel med data fra pasienter inkludert i NOSVAR (Sjøgren) ble publisert i 2020.
PÅVISNING AV NYE AUTO-ANTISTOFFER VED SYSTEMISK BINDEVEVSSYKDOMMER
Prosjektleder: Forsker Fridtjof Lund–Johansen Avdeling for immunologi og transfusjonsmedisin
Prosjektmedarbeidere: Avdelingsleder Øyvind Molberg
Rek sør-øst: 2018/674 Utfallsrelaterte biomarkører ved systemiske inflammatoriske revmatiske sykdommer
Flere hundre selskaper verden over konkurrerer i dag om å selge over en million forskjellige antistoffer til forksere og diagnostiske laboratorier. Mange er av dårlig kvalitet, og binder ikke de proteiner de er laget for. Hensikten med denne studien er å finne ut om ny teknologi kan hjelpe oss til å identifisere flere auto antistoffer ved systemiske bindevevs sykdommer på tvers av diagnosene Sle, MCTD og SSc. Undersøkelsen av ulike serum bestanddeler gjennomføres ved hjelp av egnet undersøkelsesmetodikk (ELISA, multiplex assays og proteomikk-baserte assays) og (2) karakterisering av immunkompetente celler fra blod ved hjelp av overflatemarkør-analyser og biokjemiske undersøkelser. Artikkelskriving pågår
IDENTIFISERING AV POTENSIELLE PATOGENE T-CELLER FRA BLOD FRA PASIENTER MED SYSTEMISK SKLEROSE OG SLE
Prosjektleder: Postdoc. Asbjørn Christophersen, Immunologisk institutt, OUS
Prosjektmedarbeider: avdelingsleder Øyvind Molberg
Rek sør-øst: 2018/674 Utfallsrelaterte biomarkører ved systemiske inflammatoriske revmatiske sykdommer. Ferske blodprøver av SSc og SLE pasienter inkludert i NOSVAR ble levert til analyse m/massecytometri som kan identifisere over 40 overflatemarkører på celler. Prosjektet er et samarbeid mellom Immunologisk institutt og Stanford University, California. Den første artikkelen fra prosjektet er under revisjon i et svært prestisjetungt tidsskrift.
GENUTTRYKK I ISOLERTE B-CELLER
Prosjektleder: Postdoc. Rasmus Iversen, Immunologisk institutt
Samarbeidspartner: Avdelingsleder Øyvind Molberg
REK sør-øst:
2018 ble det levert ferske celler fra 10 pasienter i NOSVAR. Isolerte B-lymfocytter ble sendt til USA for analyse av genutrykket i enkeltceller. En ny oppfølging med 10 nye pasienter blir utført i 2019.
SAMARBEID MED ANDRE REGISTRE
EUROPEAN SCLERODERMA AND RESEARCH GROUP
Data fra NOSVAR-pasienter med Systemisk sklerose inngår i det store felleseuropeiske forskningsnettverket European Scleroderma Trial and Research group (EUSTAR: http://www.eustar.org/ ). Nettverket har fokus på epidemiologi og nye behandlingsformer. Vi bidrar med data som er tiltenkt å føre til bedrede fremtidige behandlingsmuligheter.
EUROPEAN MYOSITIS NETWORK (KAROLINSKA SYKEHUSET), SVERIGE
Samarbeid om myositter, både epidemiologiske aspekter og prosjekter mer rettet mot sykdomsmekanismer gjøres gjennom vår deltagelse i EuMyoNet (http://myonet.eu/about-us/what-is-eumyonet/).
Publikasjoner 2021
Systemisk sklerose
Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis. Didriksen H, Molberg Ø, Fretheim H, Gude E, Jordan S, Brunborg C, Palchevskiy V, Garen T, Midtvedt Ø, Andreassen AK, Distler O, Belperio J, Hoffmann-Vold AM (2021). Arthritis Rheumatol, 73 (7), 1277-1287
Estimated glomerular filtration rate is a marker of mortality in the European Scleroderma Trials and Research Group (EUSTAR) database. Gigante A, Hoffmann-Vold AM, Fegatelli DA, Gabrielli A, Leodori G, Coleiro B, De Santis M, Dagna L, Alegre-Sancho JJ, Montecucco C, Carreira PE, Balbir-Gurman A, Doria A, Riemekasten G, Airò P, Distler J, Distler O, Rosato E, EUSTAR collaborators (2021). Rheumatology (Oxford)
Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial BMJ Open, 11 (6), Hoffmann-Vold AM, Fretheim HH, Sarna VK, Barua I, Carstens MN, Distler O, Khanna D, Volkmann ER, Midtvedt Ø, Didriksen H, Dhainaut A, Halse AK, Bakland G, Pesonen M, Olsen I, Molberg Ø (2021)
Representativeness of Systemic Sclerosis Patients in Interventional Randomized Trials: an analysis of the EUSTAR database. Rheumatology (Oxford) Iudici M, Jarlborg M, Lauper K, Müller-Ladner U, Smith V, Allanore Y, Balbir-Gurman A, Doria A, Airò P, Walker UA, Riccieri V, Vonk MC, Gabrielli A, Hoffmann-Vold AM, Szücs G, Martin T, Distler O, Courvoisier DS, EUSTAR collaborators (2021)
Computed tomography-based radiomics decodes prognostic and molecular differences in interstitial lung disease related to systemic sclerosis. Schniering J, Maciukiewicz M, Gabrys HS, Brunner M, Blüthgen C, Meier C, Braga-Lagache S, Uldry AC, Heller M, Guckenberger M, Fretheim H, Nakas CT, Hoffmann-Vold AM, Distler O, Frauenfelder T, Tanadini-Lang S, Maurer B (2021)
Anticentromere Antibody Levels and Isotypes and the Development of Systemic Sclerosis. Arthritis Rheumatol, 73 (12), 2338-2347. van Leeuwen NM, Boonstra M, Bakker JA, Grummels A, Jordan S, Liem S, Distler O, Hoffmann-Vold AM, Melsens K, Smith V, Truchetet ME, Scherer HU, Toes R, Huizinga TWJ, de Vries-Bouwstra JK (2021)
Sjøgrens syndrom
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome. Rheumatology (Oxford), 60 (2), 837-848. Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, DISSECT consortium, the ImmunoArray consortium, Meadows JRS, Rantapää-Dahlqvist S, Mandl T et al. (2021)
SLE
Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus. Ann Rheum Dis, 80 (9), 1183-1189. Reid S, Hagberg N, Sandling JK, Alexsson A, Pucholt P, Sjöwall C, Lerang K, Jönsen A, Gunnarsson I, Syvänen AC, Troldborg AM, Voss A, Bengtsson AA, Molberg Ø, Jacobsen S, Svenungsson E, Rönnblom L, Leonard D (2021)
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing. Ann Rheum Dis. 2021 Jan;80(1):109-117. doi: 10.1136/annrheumdis-2020-218636. Epub 2020 Oct 9.PMID: 33037003. Sandling JK, Pucholt P, Hultin Rosenberg L, Farias FHG, Kozyrev SV, Eloranta ML, Alexsson A, Bianchi M, Padyukov L, Bengtsson C, Jonsson R, Omdal R, Lie BA, Massarenti L, Steffensen R, Jakobsen MA, Lillevang ST; ImmunoArray Development Consortium and DISSECT consortium, Lerang K, Molberg Ø, Voss A, Troldborg A, Jacobsen S, Syvänen AC, Jönsen A, Gunnarsson I, Svenungsson E, Rantapää-Dahlqvist S, Bengtsson AA, Sjöwall C, Leonard D, Lindblad-Toh K, Rönnblom L (2021)
Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts. Reppe Moe S, Haukeland H, Molberg Ø, Lerang K (2021). J Clin Med, 10 (19)
Myositt
Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort. Arthritis Rheumatol Bianchi M, Kozyrev SV, Notarnicola A, Hultin Rosenberg L, Karlsson Å, Pucholt P, Rothwell S, Alexsson A, Sandling JK, Andersson H, Cooper RG, Padyukov L, Tjärnlund A, Dastmalchi M, ImmunoArray Development Consortium, DISSECT Consortium, Meadows JRS, Pyndt Diederichsen L, Molberg Ø, Chinoy H, Lamb J, Rönnblom L, Lindblad-Toh K, Lundberg IE (2021)
Small intestinal biopsy findings consistent with celiac disease in patients with idiopathic inflammatory myopathy: Review of existing literature. Semin Arthritis Rheum, 51 (5), 1033-1044. Nyborg GA, Molberg Ø (2021)
Vaskulitter
Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA. Rheumatology (Oxford). Dahlqvist J, Ekman D, Sennblad B, Kozyrev SV, Nordin J, Karlsson Å, Meadows JRS, Hellbacher E, Rantapää-Dahlqvist S, Berglin E, Stegmayr B, Baslund B, Palm Ø, Haukeland H, Gunnarsson I, Bruchfeld A, Segelmark M, Ohlsson S, Mohammad AJ, Svärd A, Pullerits R, Herlitz H, Söderbergh A, Rosengren Pielberg G, Hultin Rosenberg L et al. (2021)
Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis. Arthritis Res Ther, 23 (1), 18. Holme SS, Kilian K, Eggesbø HB, Moen JM, Molberg Ø (2021)
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ. Eur Respir J, 57 (3)Sikkeland LIB[TG1] , Qiao SW, Ueland T, Myrdal O, Wyrożemski Ł, Aukrust P, Jahnsen FL, Sjåheim T, Kongerud J, Molberg Ø, Lund MB, Bækkevold ES (2021)
Publikasjoner 2020
Systemisk sklerose
The power of the EUSTAR cohort: key findings to date and implications for management of systemic sclerosis patients Expert Rev Clin Immunol. Benvenuti F, Zanatta E, Avouac J, Müller-Ladner U, Cozzi F, Hoffmann-Vold AM, Gabrielli A, Distler O, Matucci-Cerinic M, Allanore Y, Doria A (2020)
Predictors of progression in systemic sclerosis patients with interstitial lung disease
Eur Respir J. Distler O, Assassi S, Cottin V, Cutolo M, Danoff SK, Denton CP, Distler JHW, Hoffmann-Vold AM, Johnson SR, Müller Ladner U,Smith V, Volkmann ER, Maher TM (2020)
ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF
BMJ Open Respir Res. Durheim MT, Hoffmann-Vold AM, Eagan TM, Hovden AO, Lund MB, Bjerke G, Birring SS, Jonassen TM, Johansen OE, Sjåheim T (2020),
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial PLoS One. Fretheim H, Chung BK, Didriksen H, Bækkevold ES, Midtvedt Ø, Brunborg C, Holm K, Valeur J, Tennøe AH, Garen T, Midtvedt T, Trøseid M, Zarè H, Lund MB, Hov JR, Lundin KEA, Molberg Ø, Hoffmann-Vold AM (2020).
Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort Rheumatology (Oxford ). Fretheim H, Halse AK, Seip M, Bitter H, Wallenius M, Garen T, Salberg A, Brunborg C, Midtvedt Ø, Molberg Ø, Hoffmann-Vold AM (2020)
Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database. Ann Rheum Dis. Hoffmann-Vold AM, Allanore Y, Alves M, Brunborg C, Airó P, Ananieva LP, Czirják L, Guiducci S, Hachulla E, Li M, Mihai C, Riemekasten G, Sfikakis PP, Kowal-Bielecka O, Riccardi A, Distler O, EUSTAR collaborators (2020)
The need for a holistic approach for SSc-ILD - achievements and ambiguity in a devastating disease Respir Res. Hoffmann-Vold AM, Allanore Y, Bendstrup E, Bruni C, Distler O, Maher TM, Wijsenbeek M, Kreuter M (2020)
The potential of fecal microbiota transplantation in systemic sclerosis Expert Rev Clin Immunol. Hoffmann-Vold AM, Fretheim H, Didriksen H, Molberg Ø (2020)
Circulating biomarkers of systemic sclerosis - interstitial lung disease J. Scleroderma Relat. Disord. Hoffmann-Vold AM, Fretheim H, Meier C, Maurer B (2020)
European consensus statements for interstitial lung disease in systemic sclerosis. Reply
Lancet Rheumatol. Hoffmann-Vold AM, Maher TM, Distler O (2020)
The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements Lancet Rheumatol. Hoffmann-Vold AM, Maher TM, Philpot EE, Ashrafzadeh A, Barake R, Barsotti S, Bruni C, Carducci P, Carreira PE, Castellvi I, Del Galdo F, Distler JHW, Foeldvari I, Fraticelli P, George PM, Griffiths B, Guillen-Del-Castillo A, Hamid AM, Horvath R, Hughes M, Kreuter M, Moazedi-Fuerst F, Olas J, Paul S, Rotondo C et al. (2020)
Detection, screening, and classification of interstitial lung disease in patients with systemic sclerosis. Curr Opin Rheumatol, Hoffmann-Vold AM, Molberg Ø (2020)
Selexipag treatment in patients with systemic sclerosis-associated pulmonary arterial hypertension in clinical practice, a case series. J. Scleroderma Relat. Disord.,Lemmers JMJ, Fretheim H, Knaapen HKA, van den Hoogen FHJ, Van Haren-Willems JHGM, Duijnhouwer AL, van Dijk AP, van den Ende CHM, Hoffmann-Vold AM, Vonk MC (2020)
Estimation of the Prevalence of Progressive Fibrosing Interstitial Lung Diseases: Systematic Literature Review and Data from a Physician Survey. Adv Ther Olson A, Hartmann N, Patnaik P, Wallace L, Schlenker-Herceg R, Nasser M, Richeldi L, Hoffmann-Vold AM, Cottin V (2020)
Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis,Spagnolo P, Distler O, Ryerson CJ, Tzouvelekis A, Lee JS, Bonella F, Bouros D, Hoffmann-Vold AM, Crestani B, Matteson EL (2020)
Sjøgrens syndrom
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
Sci Rep. Tashbayev B, Garen T, Palm Ø, Chen X, Herlofson BB, Young A, Hove LH, Rykke M, Singh PB, Aqrawi LA, Utheim ØA, Utheim TP, Jensen JL (2020)
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
Rheumatology (Oxford) (in press). Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, , , Meadows JRS, Rantapää-Dahlqvist S, Mandl T et al. (2020)
SLE
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing. Ann Rheum Dis. Sandling JK, Pucholt P, Hultin Rosenberg L, Farias FHG, Kozyrev SV, Eloranta ML, Alexsson A, Bianchi M, Padyukov L, Bengtsson C, Jonsson R, Omdal R, Lie BA, Massarenti L, Steffensen R, Jakobsen MA, Lillevang ST, ImmunoArray Development Consortium and DISSECT consortium, Lerang K, Molberg Ø, Voss A, Troldborg A, Jacobsen S, Syvänen AC, Jönsen A et al. (2020)
Vaskulitter
Impact of Paranasal Sinus Surgery in Granulomatosis With Polyangiitis: A Longitudinal Computed Tomography Study. Laryngoscop Holme SS, Moen JM, Kilian K, Eggesbø HB, Molberg Ø (2020)
Publikasjoner 2019
Systemisk sklerose
Performance of Candidate Serum Biomarkers for Systemic Sclerosis-Associated Interstitial Lung Disease. Elhai M, Hoffmann-Vold AM, Avouac J, Pezet S, Cauvet A, Leblond A, Fretheim H, Garen T, Kuwana M, Molberg Ø, Allanore Y . Arthritis Rheumatol. 2019 jun
Cyclophosphamide for Systemic Sclerosis-related Interstitial Lung Disease: A Comparison of Scleroderma Lung Study I and II. Volkmann ER et.al. (Hoffmann-Vold AM, medforfatter) J Rheumatol. 2019 Oct
Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study. Elhai M, et al for EUSTAR network (Hoffmann-Vold AM, medforfatter) Ann Rheum Dis. 2019 Jul
Setting the international standard for longitudinal follow-up of patients with systemic sclerosis: a Delphi-based expert consensus on core clinical features. Hoffmann-Vold AM1, Distler O2, Murray B3, Kowal-Bielecka O4, Khanna D5, Allanore Y6,7; EUSTAR and SCTC collaborators. RMD Open. 2019 Mar
Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.
Distler O and SENSCIS Trial Investigators. Hoffmann-Vold AM (medforfatter) N Engl J Med. 2019 Jun
Tracking Impact of Interstitial Lung Disease in Systemic Sclerosis in a Complete Nationwide Cohort.
Hoffmann-Vold AM, Fretheim H, Halse AK, Seip M, Bitter H, Wallenius M, Garen T, Salberg A, Brunborg C, Midtvedt Ø, Lund MB, Aaløkken TM, Molberg Ø. Am J Respir Crit Care Med. 2019 Nov
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
López-Isac E1et al. (Hoffmann-Vold AM, medforfatter). Nat Commun. 2019 Oct. Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study. Jaeger VK et al. Eustar network (Hoffmann-Vold AM, medforfatter). Rheumatology (Oxford). 2019 Nov
Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease. Hoffmann-Vold AM, Weigt SS, Saggar R, Palchevskiy V, Volkmann ER, Liang LL, Ross D, Ardehali A, Lynch JP 3rd, Belperio JA. EBioMedicine. 2019 Dec
Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications.
Tennøe AH, Murbræch K, Andreassen JC, Fretheim H, Midtvedt Ø, Garen T, Dalen H, Gude E, Andreassen A, Aakhus S, Molberg Ø, Hoffmann-Vold AM. ACR Open Rheumatol. 2019
Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort.
Mihai C, et.al EUSTAR nettwork, Rheumatology (Oxford). 2019 (Hoffmann-Vold AM, medforfatter) Rheumatology 2019
Sjøgrens syndrom
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers.
Aqrawi LA1, Galtung HK, Guerreiro EM, Øvstebø R, Thiede B, Utheim TP, Chen X, Utheim ØA, Palm Ø, Skarstein K, Jensen JL. Arthritis Res Ther. 2019 Jul
Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients.
Rusthen S, Kristoffersen AK, Young A, Galtung HK, Petrovski BÉ, Palm Ø, Enersen M, Jensen JL. PLoS One. 2019 Jun
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations.
Chen X, Aqrawi LA, Utheim TP, Tashbayev B, Utheim ØA, Reppe S, Hove LH, Herlofson BB, Singh PB, Palm Ø, Galtung HK, Jensen JCL. Sci Rep. 2019 May
Distorted Taste and Impaired Oral Health in Patients with Sicca Complaints
Singh PB, Young A, Homayouni A, Hove LH, Petrovski BÉ, Herlofson BB, Palm Ø, Rykke M, Jensen JL. Nutrients. 2019 Jan
SLE
Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort. Reppe Moe SE, Molberg Ø, Strøm EH, Lerang K. Lupus. 2019 Jun
Vaskulitter
Development of CT-based methods for longitudinal analyses of paranasal sinus osteitis in granulomatosis with polyangiitis
Sigrun Skaar Holme, Jon Magnus Moen,1 Karin Kilian, Hilde Haukeland, Øyvind Molberg, and Heidi B. Eggesbø, BMC Med Imaging. 2019; 19: 13.
Publikasjoner 2018
Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides. Garen T, Lerang K, Hoffmann-Vold AM, Andersson H, Midtvedt Ø, Brunborg C, Kilian K, Gudbrandsson B, Gunnarsson R, Norby G, Chaudhary A, Thoen J, Forseth KØ, Fresjar K, Førre Ø, Haugen M, Haga HJ, Gran JT, Gilboe IM, Molberg Ø, Palm Ø. Rheumatology (Oxford). 2018 Oct 3.
CCL21 as a potential biomarker for pulmonary arterial hypertension in systemic sclerosis. Hoffmann-Vold AM, Molberg Ø. Arthritis Rheumatol. 2018 Oct 3.
Left Ventricular Diastolic Dysfunction Predicts Mortality in Patients With Systemic Sclerosis. Tennøe AH, Murbræch K, Andreassen JC, Fretheim H, Garen T, Gude E, Andreassen A, Aakhus S, Molberg Ø, Hoffmann-Vold AM. J Am Coll Cardiol. 2018 Oct 9;72(15):1804-1813
Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis. Parkes JE, Rothwell S, Oldroyd A, Chinoy H, Lamb JA; Myositis Genetics Consortium (MYOGEN). Arthritis Res Ther. 2018 Jun 8;20(1):117.
Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study. Reiseter S, Gunnarsson R, Mogens Aaløkken T, Lund MB, Mynarek G, Corander J, Haydon J, Molberg Ø. Rheumatology (Oxford). 2018 Feb 1;57(2):255-262.
Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. González-Gay MA, Montecucco C, Selva-O'Callaghan A, Trallero-Araguas E, Molberg O, Andersson H, Rojas-Serrano J, Perez-Roman DI, Bauhammer J, Fiehn C, Neri R, Barsotti S, Lorenz HM, Doria A, Ghirardello A, Iannone F, Giannini M, Franceschini F, Cavazzana I, Triantafyllias K, Benucci M, Infantino M, Manfredi M, Conti F, Schwarting A, Sebastiani G, Iuliano A, Emmi G, Silvestri E, Govoni M, Scirè CA, Furini F, Lopez-Longo FJ, Martínez-Barrio J, Sebastiani M, Manfredi A, Bachiller-Corral J, Sifuentes Giraldo WA, Cimmino MA, Cosso C, Belotti Masserini A, Cagnotto G, Codullo V, Romano M, Paolazzi G, Pellerito R, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Batticciotto A, Bartoloni Bocci E, Gerli R, Specker C, Bravi E, Selmi C, Parisi S, Salaffi F, Meloni F, Marchioni E, Pesci A, Dei G, Confalonieri M, Tomietto P, Nuno L, Bonella F, Pipitone N, Mera-Valera A, Perez-Gomez N, Gerzeli S, Lopez-Mejias R, Matos-Costa CJ, Pereira da Silva JA, Cifrian J, Alpini C, Olivieri I, Blázquez Cañamero MÁ, Rodriguez Cambrón AB, Castañeda S, Cavagna L; AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group. Clin Exp Rheumatol. 2018 Jan-Feb;36(1):44-49. Epub 2017 Jul 26.
Frequencies of borderline pulmonary hypertension before and after the DETECT algorithm: results from a prospective systemic sclerosis cohort. Hoffmann-Vold AM, Fretheim H, Midtvedt Ø, Kilian K, Angelshaug M, Chaudhary A, Gunnarsson R, Brunborg C, Garen T, Andreassen AK, Gude E, Molberg Ø. Rheumatology (Oxford). 2018 Mar 1;57(3):480-487.
The EuroMyositis registry: an international collaborative tool to facilitate myositis research. Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, Oakley P, Benveniste O, Danieli MG, Danko K, Thuy NTP, Vazquez-Del Mercado M, Andersson H, De Paepe B, deBleecker JL, Maurer B, McCann LJ, Pipitone N, McHugh N, Betteridge ZE, New P, Cooper RG, Ollier WE, Lamb JA, Krogh NS, Lundberg IE, Chinoy H; all EuroMyositis contributors.Ann Rheum Dis. 2018 Jan;77(1):30-39.
Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis. Parkes JE, Rothwell S, Oldroyd A, Chinoy H, Lamb JA; Myositis Genetics Consortium (MYOGEN). Arthritis Res Ther. 2018 Jun 8;20(1):117.
Pulmonary Manifestations and Progression of Lung Disease in Juvenile-onset Mixed Connective Tissue Disease. Hetlevik SO, Flatø B, Aaløkken TM, Lund MB, Reiseter S, Mynarek GK, Nordal E, Rygg M, Lilleby V. J Rheumatol. 2018 Aug 1. pii: jrheum.180019.
Dietary Intake, Body Composition, and Oral Health Parameters among Female Patients with Primary Sjögren's Syndrome. Nesvold MB, Jensen JL, Hove LH, Singh PB, Young A, Palm Ø, Andersen LF, Carlsen MH, Iversen PO. Nutrients. 2018 Jul 4;10(7). pii: E866.
Prediction of progression of interstitial lung disease in patients with systemic sclerosis: the SPAR model. Wu W, Jordan S, Becker MO, Dobrota R, Maurer B, Fretheim H, Ye S, Siegert E, Allanore Y, Hoffmann-Vold AM, Distler O. Ann Rheum Dis. 2018 Sep;77(9):1326-1332
Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome.
Aqrawi LA, Chen X, Jensen JL, Morthen MK, Thiede B, Utheim ØA, Palm Ø, Tashbayev B, Utheim TP, Galtung HK. PLoS One. 2018 Oct 12
Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis.
Hoffmann-Vold AM, Weigt SS, Palchevskiy V, Volkmann E, Saggar R, Li N, Midtvedt Ø, Lund MB, Garen T, Fishbein MC, Ardehali A, Ross DJ, Ueland T, Aukrust P, Lynch JP 3rd, Elashoff RM, Molberg Ø, Belperio JA. PLoS One. 2018 Nov 20
Left Ventricular Diastolic Dysfunction Predicts Mortality in Patients With Systemic Sclerosis.
Tennøe AH, Murbræch K, Andreassen JC, Fretheim H, Garen T, Gude E, Andreassen A, Aakhus S, Molberg Ø, Hoffmann-Vold AM. J Am Coll Cardiol. 2018 Oct 9
The EuroMyositis registry: an international collaborative tool to facilitate myositis research.
Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, Oakley P, Benveniste O, Danieli MG, Danko K, Thuy NTP, Vazquez-Del Mercado M, Andersson H, De Paepe B, deBleecker JL, Maurer B, McCann LJ, Pipitone N, McHugh N, Betteridge ZE, New P, Cooper RG, Ollier WE, Lamb JA, Krogh NS, Lundberg IE, Chinoy H; all EuroMyositis contributors.Ann Rheum Dis. 2018 Jan;77(1):30-39.
Pulmonary Manifestations and Progression of Lung Disease in Juvenile-onset Mixed Connective Tissue Disease. Hetlevik SO, Flatø B, Aaløkken TM, Lund MB, Reiseter S, Mynarek GK, Nordal E, Rygg M, Lilleby V. J Rheumatol. 2018 Aug
Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study.
Reiseter S, Gunnarsson R, Mogens Aaløkken T, Lund MB, Mynarek G, Corander J, Haydon J, Molberg Ø. Rheumatology (Oxford). 2018 Feb 1;57(2):255-262
Publikasjoner 2017
Comparative analyses of muscle MRI and muscular function in anti-synthetase syndrome patients and matched controls: a cross-sectional study. Andersson H, Kirkhus E, Garen T, Walle-Hansen R, Merckoll E, Molberg Ø. Arthritis Res Ther. 2017 Jan 25;19(1):17. doi: 10.1186/s13075-017-1219-y.
Cardiopulmonary Disease Development in Anti-RNA Polymerase III-positive Systemic Sclerosis: Comparative Analyses from an Unselected, Prospective Patient Cohort. Hoffmann-Vold AM, Midtvedt Ø, Tennøe AH, Garen T, Lund MB, Aaløkken TM, Andreassen AK, Elhage F, Brunborg C, Taraldsrud E, Molberg Ø.J Rheumatol. 2017 Jan 15. pii: jrheum.160867. doi: 10.3899/jrheum.160867. [Epub ahead of print]
Immune-array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity across the Myositis Spectrum. Rothwell S, Cooper RG, Lundberg IE, Gregersen PK, Hanna MG, Machado PM, Herbert MK, Pruijn GJ, Lilleker JB, Roberts M, Bowes J, Seldin MF, Vencovsky J, Danko K, Limaye V, Selva-O'Callaghan A, Platt H, Molberg Ø, Benveniste O, Radstake TR, Doria A, De Bleecker J, De Paepe B, Gieger C, Meitinger T, Winkelmann J, Amos CI, Ollier WE, Padyukov L, Lee AT, Lamb JA, Chinoy H. Arthritis Rheumatol. 2017 Jan 13. doi: 10.1002/art.40045
Interdisciplinary, Comprehensive Oral and Ocular Evaluation of Patients with Primary Sjögren’s Syndrome. Tashbayev B, Rusthen S, Young A, Herlofson BB, Hove LH, Singh PB, Rykke M, Aqrawi LA, Chen X, Utheim ØA, Utheim TP, Palm Ø, Jensen JL. Sci Rep. 2017 Sep 7;7(1):10761. doi: 10.1038/s41598-017-10809-w.
Meibomian gland features in a Norwegian cohort of patients with primary Sjögren´s syndrome. Chen X, Utheim ØA, Xiao J, Adil MY, Stojanovic A, Tashbayev B, Jensen JL, Utheim TP. PLoS One. 2017 Sep 8;12(9):e0184284. doi: 10.1371/journal.pone.0184284. eCollection 2017.
Stromelysin-2 (MMP-10), a novel mediator of vascular remodeling underlying pulmonary hypertension associated with systemic sclerosis. Avouac J, Guignabert C, Hoffmann-Vold AM, Ruiz B, Dorfmuller P, Pezet S, Amar O, Tu L, Van Wassenhove J, Sadoine J, Launay D, Elhai M, Cauvet A, Subramaniam A, Resnick R, Hachulla E, Molberg Ø, Kahan A, Humbert M, Allanore Y.Arthritis Rheumatol. 2017 Aug 13. doi: 10.1002/art.40229.
Long-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients. Ramírez Sepúlveda JI, Kvarnström M, Eriksson P, Mandl T, Norheim KB, Johnsen SJ, Hammenfors D, Jonsson MV, Skarstein K, Brun JG; DISSECT consortium, Rönnblom L, Forsblad-d’Elia H, Magnusson Bucher S, Baecklund E, Theander E, Omdal R, Jonsson R, Nordmark G, Wahren-Herlenius M.Biol Sex Differ. 2017 Aug 8;8(1):25. doi: 10.1186/s13293-017-0146-6.
Oral disorders, saliva secretion, and oral health-related quality of life in patients with primary Sjögren’s syndrome. Rusthen S, Young A, Herlofson BB, Aqrawi LA, Rykke M, Hove LH, Palm Ø, Jensen JL, Singh PB.Eur J Oral Sci. 2017 Aug;125(4):265-271. doi: 10.1111/eos.12358. Epub 2017 Jun 23.
TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study. Gudbrandsson B, Molberg Ø, Palm Ø.Arthritis Res Ther. 2017 May 18;19(1):99. doi: 10.1186/s13075-017-1316-y.
Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. González-Gay MA, Montecucco C, Selva-O’Callaghan A, Trallero-Araguas E, Molberg O, Andersson H, Rojas-Serrano J, Perez-Roman DI, Bauhammer J, Fiehn C, Neri R, Barsotti S, Lorenz HM, Doria A, Ghirardello A, Iannone F, Giannini M, Franceschini F, Cavazzana I, Triantafyllias K, Benucci M, Infantino M, Manfredi M, Conti F, Schwarting A, Sebastiani G, Iuliano A, Emmi G, Silvestri E, Govoni M, Scirè CA, Furini F, Lopez-Longo FJ, Martínez-Barrio J, Sebastiani M, Manfredi A, Bachiller-Corral J, Sifuentes Giraldo WA, Cimmino MA, Cosso C, Belotti Masserini A, Cagnotto G, Codullo V, Romano M, Paolazzi G, Pellerito R, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Batticciotto A, Bartoloni Bocci E, Gerli R, Specker C, Bravi E, Selmi C, Parisi S, Salaffi F, Meloni F, Marchioni E, Pesci A, Dei G, Confalonieri M, Tomietto P, Nuno L, Bonella F, Pipitone N, Mera-Valera A, Perez-Gomez N, Gerzeli S, Lopez-Mejias R, Matos-Costa CJ, Pereira da Silva JA, Cifrian J, Alpini C, Olivieri I, Blázquez Cañamero MÁ, Rodriguez Cambrón AB, Castañeda S, Cavagna L; AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group. Clin Exp Rheumatol. 2017 Jul 26. [Epub ahead of print]
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts. Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J.BMJ Open Gastroenterol. 2017 Apr 1;4(1):e000134. doi: 10.1136/bmjgast-2017-000134. eCollection 2017.PMID:28761687
Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. Aqrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA, Palm Ø, Jensen JL. Arthritis Res Ther. 2017 Jan 25;19(1):14. doi: 10.1186/s13075-017-1228-x.
Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study. Reiseter S, Gunnarsson R, Mogens Aaløkken T, Brit Lund M, Mynarek G, Corander J, Haydon J, Molberg Ø. Rheumatology (Oxford). 2017 Mar 29. doi: 10.1093/rheumatology/kex077. [Epub ahead of print] PMID:28379478
Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum. Rothwell S, Cooper RG, Lundberg IE, Gregersen PK, Hanna MG, Machado PM, Herbert MK, Pruijn GJM, Lilleker JB, Roberts M, Bowes J, Seldin MF, Vencovsky J, Danko K, Limaye V, Selva-O’Callaghan A, Platt H, Molberg Ø, Benveniste O, Radstake TRDJ, Doria A, De Bleecker J, De Paepe B, Gieger C, Meitinger T, Winkelmann J, Amos CI, Ollier WE, Padyukov L, Lee AT, Lamb JA, Chinoy H; Myositis Genetics Consortium. Arthritis Rheumatol. 2017 May;69(5):1090-1099. doi: 10.1002/art.40045. Epub 2017 Apr 4.PMID:28086002
Publikasjoner 2016
A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis. Carmona FD, et al Am J Hum Genet. 2016 Dec 21. pii: S0002-9297(16)30491-8. doi:
Takayasu arteritis and pregnancy; – a population based study on outcome and mother-child related concerns. Gudbrandsson B, Wallenius M, Garen T, Henriksen T, Molberg Ø, Palm Ø. Arthritis Care Res (Hoboken). 2016 Nov 3. doi: 10.1002/acr.23146.
Endostatin is higher and associated with pulmonary involvement in primary Sjögren’s syndrome. Øyvind Palm, Thor Ueland, Torhild Garen, Annika E. Michelsen, Silje Reiseter, Pål Aukrust, Trond Mogens Aaløkken, Øyvind Molberg, Clin Exp Rheumatol, 2016
Prevalence, incidence and disease characteristics of Takayasu Arteritis differ by ethnic background; data from a large, population based cohort resident in Southern Norway. Gudbrandsson B, Molberg Ø, Garen T, Palm Ø. Arthritis Care Res (Hoboken). 2016 May 9. doi: 10.1002/acr.22931.
Antiphospholipid antibodies are associated with low levels of complement C3 and C4 in patients with systemic lupus erythematosus. Garabet L, Gilboe IM, Mowinckel MC, Flem Jacobsen A, Mollnes TE, Sandset PM, Jacobsen EM. Scand J Immunol. 2016 May 2. doi: 10.1111/sji.12445.
Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus. López-Isac E, et al. Arthritis Rheumatol. 2016 Apr 25. doi: 10.1002/art.39730. [Epub ahead of print]
Pulmonary Involvement in the Antisynthetase Syndrome: A Comparative Cross-sectional Study. Andersson H, Aaløkken TM, Günther A, Mynarek GK, Garen T, Lund MB, Molberg Ø. J Rheumatol. 2016 Apr 1. pii: jrheum.151067. [Epub ahead of print]
High level of chemokine CCL18 is associated with pulmonary function deterioration, lung fibrosis progression and reduced survival in Systemic Sclerosis. Hoffmann-Vold AM, Tennøe AH, Garen T, Midtvedt Ø, Abraityte A, Aaløkken TM, Lund MB, Brunborg C, Aukrust P, Ueland T, Molberg Ø. Chest. 2016 Mar 18. pii: S0012-3692(16)41642-9. doi: 10.1016/j.chest.2016.03.004. [Epub ahead of print]
Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease. Gunnarsson R, El-Hage F, Aaløkken TM, Reiseter S, Lund MB, Garen T; Norwegian MCTD study group, Molberg Ø. Rheumatology (Oxford). 2016 Jan;55(1):103-8. doi: 10.1093/rheumatology/kev300. Epub 2015 Aug 28
Publikasjoner 2015
A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility. Carmona FD et al, Am J Hum Genet. 2015 Mar 25
Long-term experience with rituximab in anti-synthetase syndrome-related interstitial lung disease. Andersson H, Sem M, Lund MB, Aaløkken TM, Günther A, Walle-Hansen R, Garen T, Molberg Ø. Rheumatology (Oxford). 2015 Mar 3. pii: kev004. [Epub ahead of print]
High prevalence of inclusion body myositis in Norway; a population-based clinical epidemiology study. Dobloug GC, Antal EA, Sveberg L, Garen T, Bitter H, Stjärne J, Grøvle L, Gran JT, Molberg Ø. Eur J Neurol. 2015 Apr;22(4):672-e41.
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study. Ingegnoli F et al EUSTAR Group: Microvasc Res. 2015 Aug 4
Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort. Dobloug GC, Garen T, Brunborg C, Gran JT, Molberg Ø. Semin Arthritis Rheum. 2015 Jun 17
Predictive Value of Serial High-Resolution Computed Tomography Analyses and Concurrent Lung Function Tests in Systemic Sclerosis. Hoffmann-Vold AM, Aaløkken TM, Lund MB, Garen T, Midtvedt Ø, Brunborg C, Gran JT, Molberg Ø. Arthritis Rheumatol. 2015 May;67
Prevalence and clinical characteristics of adult polymyositis and dermatomyositis; data from a large and unselected Norwegian cohort. Dobloug C, Garen T, Bitter H, Stjärne J, Stenseth G, Grøvle L, Sem M, Gran JT, Molberg O.Ann Rheum Dis. 2015 Aug;74
The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases. Flåm ST, Gunnarsson R, Garen T; Norwegian MCTD Study Group, Lie BA, Molberg O. Rheumatology (Oxford). 2015 Mar;54
Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database. Maurer B et al, Ann Rheum Dis. 2015 Jun;74
Performance of the 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) in Large, Well-defined Cohorts of SSc and Mixed Connective Tissue Disease. Hoffmann-Vold AM, Gunnarsson R, Garen T, Midtvedt O, Molberg O, J Rheumatol. 2015 Jan;42
Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational. Reiseter, S, Molberg, O, Gunnarsson R, Lund MB, Aalokken TM, Aukrust P, Ueland T, Garen T, Brunborg C, Michelsen A, Abraityte A, Hoffmann-Vold AM. Arthritis Res Ther. 2015 Aug 28;17:231. doi: 10.1186/s13075-015-0756-5.
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. Rothwell S, et al; Myositis Genetics Consortium.Ann Rheum Dis. 2015 Sep 11. pii: annrheumdis-2015-208119. doi: 10.1136/annrheumdis-2015-208119.
Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease. Gunnarsson R, El-Hage F, Aaløkken TM, Reiseter S, Lund MB, Garen T; Norwegian MCTD study group, Molberg Ø. Rheumatology (Oxford). 2016 Jan;55(1):103-8. doi: 10.1093/rheumatology/kev300
Publikasjoner 2014
Influence of the IL17A locus in giant cell arteritis susceptibility. Márquez A, et al. J.Ann Rheum Dis. 2014 Jun 11. pii: annrheumdis-2014-205261. doi: 10.1136/annrheumdis-2014-205261. [Epub ahead of print]
Mortality and years of potential life loss in systemic lupus erythematosus: a population-based cohort study. Lerang K, Gilboe IM, Telle SD, Gran JT; Lupus
Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group. Jordan S et al; Ann.Rheum Dis.
Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prosepctive study. Avouac J et al. Ann Rheum Dis
A gender gap in primary and secondary heart dysfunction in systemic sclerosis: a EUSTAR prospective study. Elhai M et al. Ann Rheum Dis.
Livskvalitet, munntørrhet og kliniske funn hos pasienter med Sjögrens syndrom. Melina Grigoriou, Tone Berge Enger, Helle Charlotte Øveraasen, Øyvind Palm, Torhild Garen og Janicke Liaaen Jensen. Nor Tannelgeforen Tid. 2014
A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA. Márquez A, et al. PLoS One. 2014 Nov 19;9(11):e113476.
Publikasjoner 2013
Pulmonary Involvement in Sjøgrens syndrom. Palm Ø, Garen T, Gran JT et al Rheumatology 2013
Pulmonary Hypertension in MCTD. Gunnarsson R, et al. Rheumatology 2013
Survival and causes of death in an unselected and complete cohort of Norwegian patients with systemic sclerosis. Hoffmann-Vold AM, Molberg Ø, Midtvedt Ø, Garen T, Gran JT. J Rheumatol. 2013 Jul;40(7):1127-33. doi: 10.3899/jrheum.121390. Epub 2013 May 1.
Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Diaz-Gallo LM, et al. Ann Rheum Dis. 2013 Jul;72(7):1233-8. doi: 10.1136/annrheumdis-2012-202357. Epub 2012 Nov 21
Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Serrano A, Márquez A, et al, Ann Rheum Dis. 2013 Aug 14. doi: 10.1136/annrheumdis-2013-203641.
Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Bossini-Castillo L, et al AM Hoffmann-Vold medforfatter,Ann Rheum Dis 2013;72:602-607 doi:10.1136/annrheumdis-2012-201888
Publikasjoner 2012
Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study. Gunnarsson R, et al. Ann Rheum Dis. 2012 Dec;71(12):1966-72. doi: 10.1136/annrheumdis-2011-201253
A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis. Bossini-Castillo L, AM Hoffmann-Vold medforfatter. Rheumatology (Oxford). 2011 Nov;50(11):1976-81.
Prevalence of systemic sclerosis in south-east Norway. Hoffmann-Vold AM, et al T Garen medforfatter. Rheumatology (Oxford). 2012 Sep;51(9):1600-5.
Differences between rheumatologists and other internists regarding diagnosis and treatment of systemic lupus erythematosus. Lerang K, Gilboe IM, Gran JT. Rheumatology (Oxford). 2012 Apr;51(4):663-9
High incidence and prevalence of systemic lupus erythematosus in Norway. Lerang K, Gilboe I, Garen T, Thelle D, Gran J. Lupus. 2012;21(12):1362-9
Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. Cénit MC, et al, J Rheumatol. 2012 Oct 1
Publikasjoner 2011
Oral distress in primary Sjögren’s syndrome: implications for health-related quality of life. Enger TB et al
Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Carmona FD, Ann Rheum Dis. 2011 Nov
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. Gorlova O. . PLoS Genet. 2011 Jul; 7(7)
The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Martin JE et al. Genes Immun. 2011 Oct 20.
Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Bossini-Castillo L et al. Rheumatology (Oxford). 2011 Nov.
A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Bossini-Castillo L et al. Hum Mol Genet. 2011 Nov 29.
The prevalence and incidence of mixed connective tissue disease: a national multicentre survey of Norwegian patients. Gunnarsson R, et al PAHNOR1 Study Group. Ann Rheum Dis. 2011 Jun;70(6):1047-51.
Publikasjoner 2010
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Bossini-Castillo L et al. Ann Rheum Dis. 2010 Dec 27.
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Radstake TR et al. Nat Genet. 2010 May; 42(5):426-9. Epub 2010 Apr 11.
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