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Norsk senter for cystisk fibrose Forskningsprosjekter

 

Kliniske studier ved NSCF

Vurdering av oksygenbehov ved flyreise

Vi vil undersøke om voksne med CF vil ha behov for oksygentilskudd under flyreise for å unngå lav oksygenmetning i blod, og hvordan man best kan vurdere dette før flyreisen.

​VX20​-121-103

Bruk av VX-121 ved cystisk fibrose

​Denne studien skal finne ut om det nye legemiddelet VX-121/TEZ/D-IVA er trygt å bruke. Vi skal også se om det virker bedre enn medikamentet Kaftrio som må kombineres med en kveldsdose Ivacaftor (Kalydeco). Du trenger bare å ta medisin én gang daglig med det nye legemiddelet.

Bruk av gassutvaskingsprosedyrer for å overvåke lungesykdom

​I studien skal vi undersøke hvordan gassutvaskingsprosedyrer med kalkulering av LCI kan brukes til å oppdage forverringer og måle respons på antibiotikabehandling hos barn med cystisk fibrose.

Effekt på vekst og kroppens forbrenning av næringsstoffer.
Studie av tilskudd med linolsyre for personer med cystisk fibrose

I studien skal vi undersøke betydningen av 1 års tilskudd med den essensielle fettsyren linolsyre på bl.a. vekst og lungefunksjon hos barn med cystisk fibrose (CF).
 

 

Studie av tilskudd med linolsyre for personer med cystisk fibrose​


Publikasjoner
Her finner du en oversikt over publikasjoner som ansatte ved NSCF har utgitt, eller bidratt til i samarbeid med andre fagmiljøer i Norge eller i utlandet.
 

2018:

Transfer of a bla CTX-M-1-carrying plasmid between different Escherichia coli strains within the human gut explored by whole genome sequencing analyses. Knudsen PK, Gammelsrud KW, Alfsnes K, Steinbakk M, Abrahamsen TG, Müller F, Bohlin J. Sci Rep. 2018;8(1):280. doi: 10.1038/s41598-017-18659-2.

Sonographic pancreas echogenicity in cystic fibrosis​ compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI. Engjom T, Kavaliauskiene G, Tjora E, Erchinger F, Wathle G, Lærum BN, Njølstad PR, Frøkjær JB, Gilja OH, Dimcevski G, Haldorsen IS. PLoS One. 2018;13(7):e0201019. doi: 10.1371/journal.pone.0201019.

Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients. Engjom T, Nylund K, Erchinger F, Stangeland M, Lærum BN, Mézl M, Jiřík R, Gilja OH, Dimcevski G. BMC Med Imaging. 2018;18(1):14. doi: 10.1186/s12880-018-0259-3.

Kronisk pankreatitt – utredning og behandling. Engjom T, Waage A, Hoem D, Kvamme JM, Hauge T, Dimcevski G. Tidsskr Nor Laegeforen. 2018;138(3). doi: 10.4045/tidsskr.17.0341.

Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging. Engjom T, Tjora E, Wathle G, Erchinger F, Lærum BN, Gilja OH, Haldorsen IS, Dimcevski G. Eur Radiol. 2018;28(4):1495-1503. doi: 10.1007/s00330-017-5115-2.

2017:

Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting. Knudsen PK, Brandtzaeg P, Høiby EA, Bohlin J, Samuelsen Ø, Steinbakk M, Abrahamsen TG, Müller F, Gammelsrud KW. PLoS One. 2017;12(11):e0187618. doi: 10.1371/journal.pone.0187618.

Evaluation of a novel technique in airway clearance therapy - Specific Cough Technique (SCT) in cystic fibrosis: A pilot study of a series of N-of-1 randomised controlled trials. Gursli S, Sandvik L, Bakkeheim E, Skrede B, Stuge B. SAGE Open Med. 2017;5:2050312117697505. doi: 10.1177/2050312117697505.

Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study. Edvardsen E, Akerø A, Skjønsberg OH, Skrede B. BMC Res Notes. 2017;10(1):84. doi: 10.1186/s13104-017-2386-2.

Secretin-stimulated MRI assessment of exocrine pancreatic function in patients with cystic fibrosis and healthy controls. Madzak A, Engjom T, Wathle GK, Olesen SS, Tjora E, Njølstad PR, Lærum BN, Drewes AM, Dimcevski G, Frøkjær JB, Haldorsen IS. Abdom Radiol (NY). 2017;42(3):890-899. doi: 10.1007/s00261-016-0972-8.

2016:

En syv måneder gammel jente med svette føtter. Gjerstad AC, Storrøsten OT, Bakkeheim E, Handeland K, Bangstad HJ. Tidsskr Nor Laegeforen. 2016;136(19):1609.

A novel Direct MIC-gradient Strip Method to screen for antibiotic-resistant faecal Enterobacteriaceae. Gammelsrud KW, Knudsen PK, Høiby EA.J Microbiol Methods. 2016;129:94-97. doi: 10.1016/j.mimet.2016.08.007.

Implementation of newborn screening for cystic fibrosis in Norway. Results from the first three years. Lundman E, Gaup HJ, Bakkeheim E, Olafsdottir EJ, Rootwelt T, Storrøsten OT, Pettersen RD. J Cyst Fibros. 2016;15(3):318-24. doi: 10.1016/j.jcf.2015.12.017.

2015

Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia. Qvist T, Gilljam M, Jönsson B, Taylor-Robinson D, Jensen-Fangel S, Wang M, Svahn A, Kötz K, Hansson L, Hollsing A, Hansen CR, Finstad PL, Pressler T, Høiby N, Katzenstein TL; Scandinavian Cystic Fibrosis Study Consortium (SCFSC). J Cyst Fibros. 2015;14(1):46-52. doi: 10.1016/j.jcf.2014.08.002.

Diagnostic Accuracy of a Short Endoscopic Secretin Test in Patients With Cystic Fibrosis. Engjom T, Erchinger F, Lærum BN, Tjora E, Aksnes L, Gilja OH, Dimcevski G. Pancreas. 2015;44(8):1266-72. doi: 10.1097/MPA.0000000000000425.

Ultrasound echo-intensity predicts severe pancreatic affection in cystic fibrosis patients. Engjom T, Erchinger F, Lærum BN, Tjora E, Gilja OH, Dimcevski G. PLoS One. 2015;10(3):e0121121. doi: 10.1371/journal.pone.0121121

Diagnostic accuracy of secretin-stimulated ultrasonography of the pancreas assessing exocrine pancreatic failure in cystic fibrosis and chronic pancreatitis. Engjom T, Erchinger F, Tjora E, Lærum BN, Georg D, Gilja OH. Scand J Gastroenterol. 2015;50(5):601-10. doi: 10.3109/00365521.2015.1004363

2012

Cystic fibrosis research in allied health and nursing professions. Bradley JM, Madge S, Morton AM, Quittner AL, Elborn JS; Allied Health and Nursing Professions Working Group, European Cystic Fibrosis Society. J Cyst Fibros. 2012;11(5):387-92. doi: 10.1016/j.jcf.2012.03.004.

2011

Dietary intake and nutritional status in a Scandinavian adult cystic fibrosis-population compared with recommendations. Moen IE, Nilsson K, Andersson A, Fagerland MW, Fluge G, Hollsing A, Gilljam M, Mared L, Pressler T, Santi H, Storrøsten OT, Hjelte L. Food Nutr Res. 2011;55. doi: 10.3402/fnr.v55i0.7561.

2019:

A consensus definition for pulmonary exacerbations in children and adults with PCD for use in clinical trials. 
Lucas JS, Gahleitner F, Amorim A, et al. Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials. ERJ Open Res 2019; 5: 00147-2018. doi.org/10.1183/23120541.00147-2018

2018:

Variation in treatment strategies for the eradication of Pseudomonas aeruginosa in primary ciliary dyskinesia across European centers. Crowley S, Holgersen MG, Nielsen KG. Chron Respir Dis. 2018:1479972318787919. doi: 10.1177/1479972318787919.

Lung function in patients with primary ciliary dyskinesia: an iPCD Cohort study. Halbeisen FS, Goutaki M, Spycher BD, et al. Eur Respir J 2018; 52: 1801040. doi.org/10.1183/13993003.01040-2018.

2017:

Growth and nutritional status, and their association with lung function: a study from the international Primary Ciliary Dyskinesia Cohort. Goutaki M, Halbeisen FS, Spycher BD, Maurer E, Belle F, Amirav I, Behan L, Boon M, Carr S, Casaulta C, Clement A, Crowley S, Dell S, Ferkol T, Haarman EG, Karadag B, Knowles M, Koerner-Rettberg C, Leigh MW, Loebinger MR, Mazurek H, Morgan L, Nielsen KG, Phillipsen M, Sagel SD, Santamaria F, Schwerk N, Yiallouros P, Lucas JS, Kuehni CE; PCD Israeli Consortium; Swiss PCD Group; French Reference Centre for Rare Lung Diseases. Eur Respir J. 2017;50(6). pii: 1701659. doi: 10.1183/13993003.01659-2017.

Protracted bacterial bronchitis in children. Øymar K, Mikalsen IB, Crowley S. Tidsskr Nor Laegeforen. 2017;137(14-15). doi: 10.4045/tidsskr.16.0843.

2016:

The international primary ciliary dyskinesia cohort (iPCD Cohort): methods and first results. Goutaki M, Maurer E, Halbeisen FS, Amirav I, Barbato A, Behan L, Boon M, Casaulta C, Clement A, Crowley S, Haarman E, Hogg C, Karadag B, Koerner-Rettberg C, Leigh MW, Loebinger MR, Mazurek H, Morgan L, Nielsen KG, Omran H, Schwerk N, Scigliano S, Werner C, Yiallouros P, Zivkovic Z, Lucas JS, Kuehni CE; PCD Italian Consortium; Swiss PCD Group; French Reference Centre for Rare Lung Diseases; Genetic Disorders of Mucociliary Clearance Consortium. Eur Respir J. 2017;49(1). pii: 1601181. doi: 10.1183/13993003.01181-2016.

Primær ciliedyskinesi. Crowley S. Tidsskr Nor Laegeforen. 2016;136(2):128-30. doi: 10.4045/tidsskr.15.0390.





Last updated 6/23/2023